The intervention role of telmisartan on left ventricular hypertrophy and C reactive protein in essential hypertension patients

Objective To explore the relationship between C reactive protein(CRP) and left ventricular hypertrophy(LVH) and to examine whether angiotensin receptors antagonist ARB could decrease CRP expression,block or invert the progression of LVH with essential hypertension(EH).Methods 49 EH patients were divided into non-LVH group(n=23) and LVH group(n=26) by Devereux standard.All patients received telmisartan therapy for 24 w to detect blood pressure,hs-CRP and left ventricular mass index(LVMI).Results The hs-CRP level of LVH group was higher than that of non-LVH group.Hs-CRP was positively correlated with LVMI.Hs-CRP decreased obviously in non-LVH and LVH groups after treatment.LVMI decreased significantly than before treatment in LVH group(P0.01).Conclusions Plasma CRP level is an independent risk factor for the development of LVH in EH.Telmisatan treatment can decrease the incident LVH by reducing CRP.