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2012•Journal of Critical Care in Internal MedicineRequires access

Clinical study on evaluation of liver fibrosis by Fibroscan in patients with chronic hepatitis B

Ning Qi

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Abstract

Objective:To investigate clinical application of transient elastography (Fibroscan ) in patients with chronic hepatitis B (CHB).Methods:A total of 310 CHB patients including 23 patients with severe chronic liver failure(SCLF)and 65 patients with liver cirrhosis (LC) diagnosed by clinical manifestations were involved in the study. Liver stiffness (LS) was detected by Fibroscan device.HBV serum markers,HBV DNA level,alanine transaminase (ALT) and total billirubin (TBil) were also detected simultaneously.Results:CHB patients with LC showed significant higher LS than those without LC.Severe liver inflammation,such as SCLF,also with increased LS.Age and gender tended to affect LS.Conclusions:Fibroscan is an effective method for assessing liver fibrosis and diagnosing LC in patients with CHB.Some influential factors,such as liver inflammation,age and gender,should be taken into consideration when we analyze individual cases.

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What this paper is about

Objective:To investigate clinical application of transient elastography (Fibroscan ) in patients with chronic hepatitis B (CHB).Methods:A total of 310 CHB patients including 23 patients with severe chronic liver failure(SCLF)and 65 patients with liver cirrhosis (LC) diagnosed by clinical manifestations were involved in the study. Liver stiffness (LS) was detected by Fibroscan device.HBV serum markers,HBV DNA level,alanine transaminase (ALT) and total billirubin (TBil) were also detected simultaneously.Results:CHB patients with LC showed significant higher LS than those without LC.Severe liver inflammation,such as SCLF,also with increased LS.Age and gender tended to affect LS.Conclusions:Fibroscan is an effective method for assessing liver fibrosis and diagnosing LC in patients with CHB.Some influential factors,such as liver inflammation,age and gender,should be taken into consideration when we analyze individual cases.

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Available abstract

Objective:To investigate clinical application of transient elastography (Fibroscan ) in patients with chronic hepatitis B (CHB).Methods:A total of 310 CHB patients including 23 patients with severe chronic liver failure(SCLF)and 65 patients with liver cirrhosis (LC) diagnosed by clinical manifestations were involved in the study. Liver stiffness (LS) was detected by Fibroscan device.HBV serum markers,HBV DNA level,alanine transaminase (ALT) and total billirubin (TBil) were also detected simultaneously.Results:CHB patients with LC showed significant higher LS than those without LC.Severe liver inflammation,such as SCLF,also with increased LS.Age and gender tended to affect LS.Conclusions:Fibroscan is an effective method for assessing liver fibrosis and diagnosing LC in patients with CHB.Some influential factors,such as liver inflammation,age and gender,should be taken into consideration when we analyze individual cases.

Key concepts: Medicine, Transient elastography, Internal medicine, Gastroenterology, Cirrhosis, Alanine transaminase, Fibrosis, Hepatitis B

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