Clinical Significance of Plasma Uric Acid Measurement in Pregnancy Induced Hyper tension

Objective: To investigate the clinical significance of plasma uric acid measurement in pregnancy induced hypertension (PIH) patients. Methods: A total of 156 PIH patients and 156 normal pregnant women who were hospitalized entered this study. The plasma uric acid was tested with uricase assay. The blood urea nitrogen (BUN), creatinine (Cr), hematocrit (Hct) and platelet (Pt) count were measured at the same time. Results: The plasma uric acid concentrations were significantly higher in PIH group than those in normal pregnant group [(347.2±107. 6)μmol/L vs (235. 5±43. 2)μmol/L, P 0. 01]; It has shown that there was a positive correlation between uric acid concentration and the disease severity[r(1)=0.39, r(2)=0.48, r(3)=0.59, P 0.05]; There was a trend that the increased UA was associated with an increase of BUN, Cr, Hct and a decrease of platelet count; There was significantly higher perinatal mortality in PIH group than that in normal pregnant women when plasma uric acid was above 350 μmol/L( P0.01). Conclusion:The plasma uric acid levels are believed to be the reflection of patients in progression of PIH and can be used as a biochemical marker for judging the fetal outcome.