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2012•Journal of Wenzhou Medical CollegeRequires access

Early changes of aquaporin-4 in the hippocampus of rats following whole brain irradiation

Mi Zhu

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Abstract

Objective:To observe the early change of aquaporin-4 mRNA(AQP4 mRNA) expression in the hippocampus of rats following whole brain irradiation and its role in the early phase irradiation-induced brain injury.Methods: Thirty six female Sprague-Dawley rats were randomly divided into sham-irradiation group,and irradiation groups.The latter groups received whole brain irradiation with a single-dose of 20 Gy 6MV X-ray 1 day,1,2,4,8 weeks after irradiation,AQP4 mRNA of hippocampus tissue was measured with RT-PCR method.Results: Compared with the sham-irradiation group,AQP4 mRNA expression in the hippocampus after 20 Gy irradiation decreases in 1 day and reaches the lowest in 1 week(P0.01),and then increases after 4 weeks(P0.01),8 weeks(P0.05).Conclusion: Auaporin-4 expression in the rat hippocampus plays an important role in the brain edema after whole brain irradiation.

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Objective:To observe the early change of aquaporin-4 mRNA(AQP4 mRNA) expression in the hippocampus of rats following whole brain irradiation and its role in the early phase irradiation-induced brain injury.Methods: Thirty six female Sprague-Dawley rats were randomly divided into sham-irradiation group,and irradiation groups.The latter groups received whole brain irradiation with a single-dose of 20 Gy 6MV X-ray 1 day,1,2,4,8 weeks after irradiation,AQP4 mRNA of hippocampus tissue was measured with RT-PCR method.Results: Compared with the sham-irradiation group,AQP4 mRNA expression in the hippocampus after 20 Gy irradiation decreases in 1 day and reaches the lowest in 1 week(P0.01),and then increases after 4 weeks(P0.01),8 weeks(P0.05).Conclusion: Auaporin-4 expression in the rat hippocampus plays an important role in the brain edema after whole brain irradiation.

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Available abstract

Objective:To observe the early change of aquaporin-4 mRNA(AQP4 mRNA) expression in the hippocampus of rats following whole brain irradiation and its role in the early phase irradiation-induced brain injury.Methods: Thirty six female Sprague-Dawley rats were randomly divided into sham-irradiation group,and irradiation groups.The latter groups received whole brain irradiation with a single-dose of 20 Gy 6MV X-ray 1 day,1,2,4,8 weeks after irradiation,AQP4 mRNA of hippocampus tissue was measured with RT-PCR method.Results: Compared with the sham-irradiation group,AQP4 mRNA expression in the hippocampus after 20 Gy irradiation decreases in 1 day and reaches the lowest in 1 week(P0.01),and then increases after 4 weeks(P0.01),8 weeks(P0.05).Conclusion: Auaporin-4 expression in the rat hippocampus plays an important role in the brain edema after whole brain irradiation.

Key concepts: Hippocampus, Irradiation, Messenger RNA, Internal medicine, Endocrinology, Brain edema, Edema, Medicine

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Early changes of aquaporin-4 in the hippocampus of rats following whole brain irradiation — Research Paper | ScholarLens