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2009•Acta Laboratorium Animalis Scientia SinicaRequires access

Establishment of a Mouse Model of Bronchopulmonary Dysplasia

Jiang Duan

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Abstract

Objective To establish a mouse model of bronchopulmonary dysplasia.Method Thirty female mouse pups were randomly devided into two groups: the normoxia group(FiO_2 0.21,n = 15) and hyperoxia group(FiO_2 0.6,n = 15).Morphological changes of lung tissue,radical alveolar counts(RAC) and collagen were detected on the 7th,14th and 21th days after exposure.Results Hyperoxia-treated mice had lower body weight than those of normoxia group(P0.001).The lung tissues stained with HE of the hyperoxia group showed loss of normal alveoli,alveolar fusion and increased septal wall thickness.The RAC value was significantly decreased in the hyperoxia group(P0.001).Mice of hyperoxia group dipicted prominent proliferation of collagen(P0.001).Conclusion Exposure to oxygen(FiO_2 0.6)can induce BPD-like changes in the lung structure of mice.

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Objective To establish a mouse model of bronchopulmonary dysplasia.Method Thirty female mouse pups were randomly devided into two groups: the normoxia group(FiO_2 0.21,n = 15) and hyperoxia group(FiO_2 0.6,n = 15).Morphological changes of lung tissue,radical alveolar counts(RAC) and collagen were detected on the 7th,14th and 21th days after exposure.Results Hyperoxia-treated mice had lower body weight than those of normoxia group(P0.001).The lung tissues stained with HE of the hyperoxia group showed loss of normal alveoli,alveolar fusion and increased septal wall thickness.The RAC value was significantly decreased in the hyperoxia group(P0.001).Mice of hyperoxia group dipicted prominent proliferation of collagen(P0.001).Conclusion Exposure to oxygen(FiO_2 0.6)can induce BPD-like changes in the lung structure of mice.

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Available abstract

Objective To establish a mouse model of bronchopulmonary dysplasia.Method Thirty female mouse pups were randomly devided into two groups: the normoxia group(FiO_2 0.21,n = 15) and hyperoxia group(FiO_2 0.6,n = 15).Morphological changes of lung tissue,radical alveolar counts(RAC) and collagen were detected on the 7th,14th and 21th days after exposure.Results Hyperoxia-treated mice had lower body weight than those of normoxia group(P0.001).The lung tissues stained with HE of the hyperoxia group showed loss of normal alveoli,alveolar fusion and increased septal wall thickness.The RAC value was significantly decreased in the hyperoxia group(P0.001).Mice of hyperoxia group dipicted prominent proliferation of collagen(P0.001).Conclusion Exposure to oxygen(FiO_2 0.6)can induce BPD-like changes in the lung structure of mice.

Key concepts: Hyperoxia, Bronchopulmonary dysplasia, Lung, Medicine, Oxygen toxicity, Internal medicine, Pathology, Rat model

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