Relationship between serum uric acid concentration and non-alcoholic fatty liver disease in T2DM patients

Objective To investigate the relationship between serum SUA levels and non-alcoholic fatty liver disease(NAFLD) in T2DM patients.Methods A total of 790 T2DM subjects were enrolled in this study.Clinical experimental indices were detected.The abdominal Doppler ultrasonic examination was applied for diagnosis of NAFLD.The patients were divided into NAFLD group(n=219) and non-NAFLD group(n=571).According to the SUA levels(μmol/L) with quartiles grouping,the patients were divided into four SUA groups: Q1 group(≤230 μmol/L,n=202),Q2 group(231~287 μmol/L,n=194),Q3 group(288~350 μmol/L,n=194),and Q4 group(≥350,n=200).Results BMI,ALT,AST,γ-glutamyltransferase(GGT),TC,TG,LDL-C,and SUA were significantly higher in the NAFLD group than in the non-NAFLD group(P0.05).The age and HDL-C in the NAFLD group were significantly lower than in the non-NAFLD group(P0.05).There were no statistical differences of other indexes between them.The prevalence of NAFLD in Q1~Q4 groups was 16.8%(34/202),22.6%(44/194),30.9%(60/194) and 40.5%(81/200) respectively,and the differences among the four groups were statistically significant.After adjusting the related factors,the risk for prevalence of NAFLD in Q4 group was still significantly higher than that in Q1 group [OR(95%CI):3.19(1.38~7.39)].Conclusion The serum uric acid level in subjects with T2DM was significantly related with NAFLD.A higher SUA level may be one of the factors independently related to NAFLD in T2DM patients.