Clinical significance of detection of Cystatin C in early diagnosis of diabetic nephropathy

Objective To explore the Clinical significance of detection of serum cystatin C in the early diagnosis of type 2 diabetic nephropathy.Methods A total of 115 patients with type 2 diabetes were enrolled for the analysis.Based on the different amounts of urine albumin excretion of 24 hours,all of the patients were divided into three groups:①simple diabetic group;②early DN group;③clinical DN group.Cystatin C,blood urea nitrogen,serum creatinine and serum chemical parameters were measured,glomerular filtration rate and creatinine clearance were calculated.The different parameters' detection rate of renal dysfunction at different levels of proteinuria were compared and the correlation between Cys-c and glomerular filtration rate were analysed.The patients with normal albuminuria were divided into two groups according to eGFR.Serum cystatin C and other indicators were compared and analyzed statistically.Results The detection rate of both serum cystatin C and clearance of creatinine had no statistical difference(p0.05),was higher than that of both serum creatinine and blood urea nitrogen(p0.01).Especially in the normal albuminuria group,the detection rate of clearance of creatinine and blood urine nitrogen were very low.Cystatin C and glomerular filtration rate had a good correlation,r=-0.625.Conclusion The serum cystatin C and glomerular filtration rate have good correlation,and serum cystatin C can indicate an early decline in glomerular filtration rate in diabetic patients with normal proteinuria.