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Evaluation of Type VII Collagenase-induced Intracerebral Hemorrhage in Rats

Tang Zhou-pin

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Abstract

Objective: To evaluate the animal model of intracerebral hemorrhage(ICH) induced by injection of collagenase type Ⅶ into the right basal ganglia in rats.Methods: Collagenase type Ⅶ was injected into the right basal ganglia of rats by stereotatic technique to induce ICH.The neurological symptoms,volume of hematoma and histopathological changes were evaluated at 1,3 and 7 d after operation.Results: Neurological deficit was found in all the rats with ICH and the neurological deficit score at 3 d was higher than those at 1 and 7 d after operation(P0.05).The hematoma volume at 3 d was larger than those at 1 and 7 d after operation(P0.05).Typical histopathological changes of ICH were detected around the hematoma.Conclusion: Collagenase type Ⅶ induced ICH in rats is an ideal animal model to mimic the ICH of human.

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Objective: To evaluate the animal model of intracerebral hemorrhage(ICH) induced by injection of collagenase type Ⅶ into the right basal ganglia in rats.Methods: Collagenase type Ⅶ was injected into the right basal ganglia of rats by stereotatic technique to induce ICH.The neurological symptoms,volume of hematoma and histopathological changes were evaluated at 1,3 and 7 d after operation.Results: Neurological deficit was found in all the rats with ICH and the neurological deficit score at 3 d was higher than those at 1 and 7 d after operation(P0.05).The hematoma volume at 3 d was larger than those at 1 and 7 d after operation(P0.05).Typical histopathological changes of ICH were detected around the hematoma.Conclusion: Collagenase type Ⅶ induced ICH in rats is an ideal animal model to mimic the ICH of human.

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Available abstract

Objective: To evaluate the animal model of intracerebral hemorrhage(ICH) induced by injection of collagenase type Ⅶ into the right basal ganglia in rats.Methods: Collagenase type Ⅶ was injected into the right basal ganglia of rats by stereotatic technique to induce ICH.The neurological symptoms,volume of hematoma and histopathological changes were evaluated at 1,3 and 7 d after operation.Results: Neurological deficit was found in all the rats with ICH and the neurological deficit score at 3 d was higher than those at 1 and 7 d after operation(P0.05).The hematoma volume at 3 d was larger than those at 1 and 7 d after operation(P0.05).Typical histopathological changes of ICH were detected around the hematoma.Conclusion: Collagenase type Ⅶ induced ICH in rats is an ideal animal model to mimic the ICH of human.

Key concepts: Collagenase, Intracerebral hemorrhage, Hematoma, Basal ganglia, Medicine, Animal model, Rat model, Basal (medicine)

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