Relationship between the models of serologic markers and the quantities of virus in patients infected with hepatitis B virus

Objective: To understand the relationship between the models of serologic markers and the quantities of hepatitis B virus (HBV). Methods: The serologic markers of HBV in 670 patients were detected by using the enzyme immunoassay and the quantities of HBV in those were measured by using the real-time fluorescent quantitative PCR. Results: The HBeAg-positive patients whose copies were more than 5.0×104 cps /mL accounted for 96.3%,and the HBeAg-negative patients whose copies were more than 5.0×104 cps/mL accounted for 74.8%.The HBV copies of HBeAg-positive patients were significantly higher than HBeAg-negative patients(P0.05). The HBV copies of anti-HBe-positive patients were significantly less than anti-HBe-negative patients(P0.01).The HBV-DNA was detected in some HBsAg-negative (anti-HBs-positive or not) patients.Conclusion:: The HBV copies of HBeAg-positive patients are significantly higher than HBeAg-negative patients. However, some HBeAg-positive patients' HBV copies are very low,and some HBeAg-negative patients' HBV copies are very high.The HBV-DNA could be even detected in some HBsAg-negative (anti-HBs-positive or not) patients.It is helpful to judge accurately prognosis by testing the serologic marker and the quantities of virus.