Clinical studies on treatment with galic injection for 101 patients with acutely cerebral infarction

Objective:To investigate the curative effects of galic injection on acutely cerebral infarction(ACI) and its mechanisms.Methods:154 cases with ACI were randomly divided into two groups.The galic group was treated with galic injection 60 mg+5% glucose 500 ml infused intravenously but the tetramethylpyrazine group treated with tetramethylpyrazine injection 80 mg+5% glucose 500 ml infused intravenously once a day for two weeks as a therapeutic course in both two groups.Otherwise the symptomatic therapy was used simultaneously.The curative effects were observed,the concentration of malondialdehyde(MDA) and the parameters of blood rheology,white blood cell(WBC) rheology,and volume of cerebral blood flow were measured and compared to normal subjects.Results:By the end of twoweek therapy the total effective rate (77 23%) in galic group was significantly higher than that (62 26%) in tetramethylpyrazine group( P 0 05).After two weeks and four weeks therapy the decrease in scores of nervous functional defects and the improvement of nervous functions in galic group were superior to those in tetramethylpyrazine group.The level of serum MDA in patients with ACI was significantly higher than that in normal subjects ( P 0 01).In the time of threeweek therapy the concentration of MDA in galic group was significantly lower than that in tetramethylpyrazine group( P 0 01).The galic injection was also able to improve the filterable index of WBC,parameters of blood rheology,and cerebral blood flow.Conclusions:The galic injection can improve the blood rheology and increase the volume of cerebral blood flow at the same time it is able to eliminate oxygen free radicals,improve cerebral functions,and relieve ischemiareperfusion damage in ACI so that it can be used to treat ACI and curative effects are superior to those of tetramethylpyrazine injection.