2009•Zhonghua zhongyiyao xuekanRequires access

Experimental Research Endothelium-derived Relaxing Factor of Kats With Pulmonary Hypertension of Feixinping

Yang Ji-wu

Abstract

Objective:To study the effect of Feixinping on function of endothelial cells in rats with pulmonary hypertension in pulmonary heart disease,and probe in to the action mechanism of Feixinping in treating pulmonary hypertension in pulmonary heart disease.Methods:Rat model of pulmonary hypertension in pulmonary heart disease was duplicated by injection of 2% monocrotaline at dosage of 60mg/kg peritonially at one time.Endothelin(ET) and nitrogen monoxide(NO) level in blood were assayed by radioimmunoassay and chromatometry.Results:Compared to normal group,in model group ET increase,NO decrease significantly.Compared to model group,in Feixingping and Catopril group ET decrease,NO increase.Conclusion:Feixinping is of good therapeutic effect in treating pulmonary hypertension in pulmonary heart disease.The action of mechanism might be:Feixinping can decrease ET levels,increase NO level in rats with pulmonary hypertension in pulmonary heart disease,impel the balance of NO/ET,protect the function of endothelial cells.

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Key concepts: Pulmonary hypertension, Medicine, Endothelin receptor, Pulmonary function testing, Internal medicine, Cardiology, Endothelium, Lung