2004•Unpublished venueRequires access

THERAPEUTICAL EFFECT OF BASIC FIBROBLAST GROWTH FACTOR ON DIFFUSE AXONAL INJURY IN RATS

Xinguo Cui

Abstract

Objective:To investigate the neuroprotective effect of basic fibroblast growth factor(bFGF) on diffuse axonal injury(DAI).Methods:Fifty four Sprague Dawley rats were randomly divided into three groups,control,trauma and treatment.In the treatment group,bFGF was administered intraperitoneally immediately following diffuse axonal injury.The contents of SOD,MDA and Ca 2+ in white matter of brain were measured at 0,12,24,72 and 120 h after brain trauma.Results:Compared with those in control group,the contents of SOD decreased significantly in trauma group ( P 0 05).However,the contents of MDA and Ca 2+ in treatment group were significantly lower than those in trauma group( P 0 05).Conclusion:bFGF used in early stage can inhibit the increase of free radicals and the calcium overload in brain white matter and attenuate diffuse axonal injury.

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Key concepts: Basic fibroblast growth factor, Diffuse axonal injury, Neuroprotection, White matter, Medicine, Traumatic brain injury, Endocrinology, Internal medicine