Comparison of esomeprazole-and omeprazole based triple therapy regimens for duodenal ulcer with Helicobacter pylori infection

Objective:To investigate the efect of esomeprazole-and omeprazole based triple therapy regimens in the treatment of duodenal ulcer with Helicobacter pylori(Hp)infection.Methods:124 patients with duodenal ulcer and Hp infection were randomly divided into group A(62 cases)treated with esomeprazole(20mg),amoxicillin(1000 mg)and clarithromycin(500 mg)twice daily and group B(62 cases)treated with omeprazole(20 mg),amoxicillin(1000 mg)and clarithromycin(500 mg)twice daily.The treatment lasted for 7 days,after which abdominal pain relief rate,ulcer healing rate and eradication rate of Hp as well as adverse efects of the medication were evaluated and compared. Results:On the first and second days of medication,the abdominal pain relief rates were 35.8% and 60.2% respectively in group A,significantly higher than those ingroup B(16.5%and 40.3%,respectively,P0.05).Ulcer healing rate and Hp eradication rate were 93.6% and 93.6%in group A and 87.9%and 83.7% in group B,showing no significant diferences between the two groups P0.05).The adverse effects ofthe medication were rare in both groups without significant differences. Conclusion:Esomeprazole based triple therapy may effectively eradicate Hp infection and promote duodenal ulcer healing with good tolerance,capable of achieving more speedy pain relief than omeprazole based therapy.