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2006•Xinxueguan kangfu yixue zazhiRequires access

Effect of AG490 on hypertrophy of cardiomyocytes induced by cardiotrophin-1

Bo Yu

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Abstract

Objective:To study the effect of AG490 on hypertrophy of cardiomyocytes induced by cardiotrophin-1 (CT-1).Methods:The cultured cardiomyocytes were treated with CT-1 to induce hypertrophy of cardiomyocytes.The cell size, 3H-leucine incorporation and the mRNA levels of β-MHC were examined.Results:After stimulated by CT-1 the cardiomyocytes were enlarged(q=16.47,P0.01). Both 3H-leucine incorporation and the mRNA levels of β-MHC increased(P0.01). AG490 partly inhibited those effects of CT-1(P0.01 all).Conclusion:CT-1 may induced the cardiomyocytes hypertrophy. AG490 can partly inhibit the cardiomyocytes hypertrophy induced by CT-1.

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What this paper is about

Objective:To study the effect of AG490 on hypertrophy of cardiomyocytes induced by cardiotrophin-1 (CT-1).Methods:The cultured cardiomyocytes were treated with CT-1 to induce hypertrophy of cardiomyocytes.The cell size, 3H-leucine incorporation and the mRNA levels of β-MHC were examined.Results:After stimulated by CT-1 the cardiomyocytes were enlarged(q=16.47,P0.01). Both 3H-leucine incorporation and the mRNA levels of β-MHC increased(P0.01). AG490 partly inhibited those effects of CT-1(P0.01 all).Conclusion:CT-1 may induced the cardiomyocytes hypertrophy. AG490 can partly inhibit the cardiomyocytes hypertrophy induced by CT-1.

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Available abstract

Objective:To study the effect of AG490 on hypertrophy of cardiomyocytes induced by cardiotrophin-1 (CT-1).Methods:The cultured cardiomyocytes were treated with CT-1 to induce hypertrophy of cardiomyocytes.The cell size, 3H-leucine incorporation and the mRNA levels of β-MHC were examined.Results:After stimulated by CT-1 the cardiomyocytes were enlarged(q=16.47,P0.01). Both 3H-leucine incorporation and the mRNA levels of β-MHC increased(P0.01). AG490 partly inhibited those effects of CT-1(P0.01 all).Conclusion:CT-1 may induced the cardiomyocytes hypertrophy. AG490 can partly inhibit the cardiomyocytes hypertrophy induced by CT-1.

Key concepts: Muscle hypertrophy, Medicine, Internal medicine, Myocyte, Messenger RNA, Endocrinology, Biology, Gene

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