Short-term Efficacy Observation of Different Chemotherapy Schemes Combined with Cisplatin on Cervical Cancer before Operation

OBJECTIVE:To observe the short-term efficacy and safety of cisplatin combined with different chemotherapy schemes for cervical cancer before operation.METHODS:135 inpatients with cervical cancer in our hospital from Jan.2009 to Dec.2011 were randomly divided into first treatment group(67 cases) and second treatment group(68 cases).First treatment group received irinotecan(60 mg.m-2,d 1,d 8)combined with cisplatin chemotherapy(60 mg.m-2,d 2);second treatment group was given leurocristine(1 mg.m-2,d 1),bleomycin(15 mg.m-2,d 1,d 2)and cisplatin chemotherapy(100 mg.m-2,d 1).15～20 days after chemotherapy,all patients received extensive hysterectomy and pelvic lymph node dissection.14 days after chemotherapy,short-term efficacy and adverse drug reaction were evaluated,and the tumor infiltration of local lesion and lymph node were checked during and after operation.RESULTS:There were no significant difference in CR,PR,ORR between 2 groups(P 0.05).Preoperative chemotherapy inhibited the local lesion significantly in 2 groups,and the operation obtained satisfactory effects.There was no statistical significance in tumor cell infiltration of peripheral tissues and pelvic lymphs between 2 groups(P0.05).There was no statistical significance in gastrointestinal reactions in 2 groups(P0.05).The degree of bone marrow suppression in first treatment group was lighter than in second treatment group(P0.01).CONCLUSION:Preoperative chemotherapy plays a positive role on improvement of disease situation.Both irinotecan combined with cisplatin and leurocristine+bleomycin combined with cisplatin obtain sound therapeutic efficacies.The degree of bone marrow suppression of the latter is more serious,but it can be improved by symptomatic treatment.