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2010•Medical Journal of National Defending Forces in Northwest ChinaRequires access

Effects of dexamethasone on cytokine levels of rabbits with pulmonary edema induced by seawater drowning

Fei Jin-xiu

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Abstract

Objective:To investigate the therapeutical effect of dexamethasone on rabbits with pulmonary edema induced by seawater drowning and detect the changes of serum IL-8,TNF-α and IL-10 levels.Methods: Forty rabbits were randomly divided into 4 groups: control group(CG),dexamethasone group(0.05 mg/kg as DG1,0.2 mg/kg as DG2,1 mg/kg as DG3).The levels of serum IL-8,TNF-α,and IL-10 were examined by ELISA.Arterial blood gas was analyzed.Results:Compared with CG,the PaO2 in DG2 and DG3 was increased(P0.05),the serum IL-8 and TNF-α levels were decreased(P0.01),the serum IL-10 levels was increased(P0.01).There was no significant difference between DG2 and DG3(P0.05).Conclusion:Dexamethasone at comparatively high dose attenuates lung injury after seawater drowning,which may be related to the IL-8,TNF-α reduction and IL-10 increase.However,higher dose(1 mg/kg) can not improve the treatment effect.

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Objective:To investigate the therapeutical effect of dexamethasone on rabbits with pulmonary edema induced by seawater drowning and detect the changes of serum IL-8,TNF-α and IL-10 levels.Methods: Forty rabbits were randomly divided into 4 groups: control group(CG),dexamethasone group(0.05 mg/kg as DG1,0.2 mg/kg as DG2,1 mg/kg as DG3).The levels of serum IL-8,TNF-α,and IL-10 were examined by ELISA.Arterial blood gas was analyzed.Results:Compared with CG,the PaO2 in DG2 and DG3 was increased(P0.05),the serum IL-8 and TNF-α levels were decreased(P0.01),the serum IL-10 levels was increased(P0.01).There was no significant difference between DG2 and DG3(P0.05).Conclusion:Dexamethasone at comparatively high dose attenuates lung injury after seawater drowning,which may be related to the IL-8,TNF-α reduction and IL-10 increase.However,higher dose(1 mg/kg) can not improve the treatment effect.

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Available abstract

Objective:To investigate the therapeutical effect of dexamethasone on rabbits with pulmonary edema induced by seawater drowning and detect the changes of serum IL-8,TNF-α and IL-10 levels.Methods: Forty rabbits were randomly divided into 4 groups: control group(CG),dexamethasone group(0.05 mg/kg as DG1,0.2 mg/kg as DG2,1 mg/kg as DG3).The levels of serum IL-8,TNF-α,and IL-10 were examined by ELISA.Arterial blood gas was analyzed.Results:Compared with CG,the PaO2 in DG2 and DG3 was increased(P0.05),the serum IL-8 and TNF-α levels were decreased(P0.01),the serum IL-10 levels was increased(P0.01).There was no significant difference between DG2 and DG3(P0.05).Conclusion:Dexamethasone at comparatively high dose attenuates lung injury after seawater drowning,which may be related to the IL-8,TNF-α reduction and IL-10 increase.However,higher dose(1 mg/kg) can not improve the treatment effect.

Key concepts: Dexamethasone, Pulmonary edema, Edema, Medicine, Interleukin 6, Internal medicine, Endocrinology, Significant difference

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