Elevated platelet in Kawasaki disease and association with serum thrombopoietin,interleukin-3,interleukin-6

Objective To study the number of platelet in children with Kawasaki disease and analyze its association with serum thrombopoietin(TPO),interleukin-3(IL-3) and interleukin-6(IL-6).Methods Thirty-five children with Kawasaki disease(KD) and 25 healthy children as control were recruited.Peripheral blood PLT,MPV,PDW were measured using automatic hematocyte analyzer and serum TPO,IL-3 and IL-6 levels were detected by ELISA methods.Results The number of platelet was slightly increased in acute phase((329.17±111.88)×109/L vs(275.12±71.09)×109 /L,(P0.05)),and significantly increased in convalescent phase((528.54±185.22)×109 /L vs(329.17±111.88)×109/L,(P0.001)).MPV in KD acute phase was also significantly higher than that in control group((8.68±1.33) fl vs(7.78±1.03) fl,(P0.001)).The serum levels of TPO,IL-3 and IL-6 in acute phase were significantly increased than those in convalescent phase and those in control group.There were significant inverse correlations between the number of platelet and TPO,IL-3,IL-6 levels,and positive correlations between MPV and TPO,IL-6.Conclusions Elevation of serum TPO,IL-3 and IL-6 may be mainly responsible for thrombocytosis in Kawasaki disease.