Expression and Clinical Significance of Pokemon and P14ARF in Esophageal Squamous Cell Cancer

Objective: To investigate the correlation of the expression of Pokemon and P14ARF in esophageal squamous cell caci-noma(ESCC)tissues,and their values for determining the clinicopathological characteristics and prognosis of ESCC.Methods: Immuno histochemical SP staining was used to detect the expressions of pokemon and P14ARF proteins in 96 ESCC tumor tissues and 20 adjacent normal tissues.Their relationship with the pathological characteristics of ESCC was analyzed.The correlation of abnormal expressions of pokemon and P14ARF was analyzed.The effects of the expressions of the two proteins on the long-term prognosis of ESCC patients were observed based on the follow-up data.Results: In normal tissues there was no Pokemon expression but the positive rate of P14ARF ex-pression was 90.0 %.In ESCC tissues,the positive rate of Pokemon and P14ARF protein were 75 % and 30.2 %,respectively.The ex-pression of Pokemon had negative correlation with expression of P14ARF(r=-0.458,P=0.000).The expression of Pokemon and P14ARF were associated with TNM staging and lymph node metastasis(P0.05).In Pokemon positive patients,the five-year survival rate was 20.8 %,which was significantly lower than that in Pokemon negative patients(P=0.004).In contrast,the five-year survival rate was 41.4 % in patients with positive expression of P14ARF,which was significantly higher than that in patients with negative expression of P14ARF(P=0.011).Conclusion: The over expression of Pokemon and the less expression of P14ARF maybe play important roles in the develop-ment of ESCC.Pokemon and P14ARF have a certain clinical significance for evaluating the prognosis of ESCC patients.