The Clinical Observation of Rabeprazole Sodium in Peptic Ulcer Treatment

Objective: To evaluate the effect and safety of Rabeprazole Sodium 10mg/d in peptic ulcer treatment comparing with omeprazole 20mg/d.Method: Patients with peptic ulcer were randomly divided into four groups.A group took Rabeprazole Sodium 10mg/d,B group took Omeprazole 20mg/d,C and D groups each took Ranitidine 150mg q.n in the base of A and B.Result: The compare of average gastric ph,average median ph,average gastric ph at night,average median ph at night and decline rate of symptom integral in the four groups: C and D groups were superior to A and B groups,while there were no difference between A and B,or C and D.The side effect rate of the four groups were 2.3%、2.6%、3.3%、3.1%.They were similar.Conclusion: Rabeprazole Sodium 10mg/d in peptic ulcer treatment were effective and safety,and the effects of easing symptoms,antagonizing gastric acid were similar to Omeprazole 20mg/d.