Clinical study and pharmacoeconomic comparison on different anesthetic solution of sevoflurane and propofol for laparoscopic surgery

Objective To compare the clinical efficacy and pharmacoeconomic analysis of different anesthetic solution of sevoflurane and propofol for laparoscopic surgery. Methods The patients(200 cases) accepted laparoscopic surgery in the Traditional Chinese Medicine Hospital of Yanggu County from January 2011 to December 2013 were randomly divided into sevoflurane(66 cases), propofol(67 cases), and combined(67 cases) groups. The patients in the three groups were given the inhalation of sevoflurane anesthesia, target-controlled infusion of propofol anesthesia, and iv propofol for induction of anesthesia-inhalation of sevoflurane for maintenance of anesthesia. The quality of anesthesia and awakening, cost of anesthesia, incidence of adverse drug reactions were compared in the three groups. At the same time, the indexes of immune response in preoperative and postoperative 3 d were detected. Results Consciousness disappearing time in sevoflurane group was significantly shorter than that in the combined group, while the time in the propofol group was longer than that in the combined group, and there were differences between the two groups(P 0.05).Consciousness disappearing time, endotracheal intubation time, directional force recovery time in the propofol group were significantly longer than those in the sevoflurane and combined groups, and there were differences between the two groups(P 0.05). Anesthesia induction costs, anesthesia maintenance costs, total cost, and per minute cost in the sevoflurane and propofol groups were significantly higher than those in the combined group, and the difference was statistically significant(P 0.05). Anesthesia induction costs, anesthesia maintenance costs, total cost, and per minute cost the in propofol group were significantly higher than those in the sevoflurane group, but additional anesthesia cost was lower than that in the sevoflurane group, and there were differences between the two groups(P 0.05). CD4, CD8, and CD4/CD8 in the three groups were no statistically significant difference in 3 d before and after surgery. The difference of CD4, CD8, and CD4/CD8 in the three groups also had no statistical significance. Conclusion In the case of similar quality of anesthesia and anesthesia recovery, iv propofol for the induction of anesthesia-inhalation of sevoflurane for maintenance of anesthesia is the most economical solution, which is worthy of clinical popularization and application.