ScholarLens Back to search
2013•The Journal of Clinical AnesthesiologyRequires access

The clinical pharmacokinetics of parecoxib in Chinese patients

Chenghai Wang

Open publisher page 1 citations

Abstract

Objective To study the clinical pharmacokinetics of parecoxib in Chinese patients. Methods Twelve patients with ASA Ⅰ orⅡ undergoing elective surgery were injected parecoxib 40 mg.Blood samples were collected at 10 , 20 , 30 , 40 , 50and 60min , and 1.5 , 2 , 4 , 6 , 8 , 12 , 16 , 20 and 24hafter injection.The plasma concentration of parecoxib and its product valdecoxib were measured with high-performance liquid chromatography.The pharmacokinetic parameters were calculated with 3P97software package.Results The clinical pharmacokinetics of parecoxib is fitted to a two-compartment model.The main pharmacokinetic parameter including Cmax was ( 31.58±13.41 ) and ( 0.91±0.21 ) μ g / ml , Tmax was ( 10.00±0.00 ) min and ( 24.00±14.30 ) min , and t 1 / 2 β was ( 1.06±0.92 ) h and ( 10.65±3.20 ) h , respectively.Conclusion The clinical pharmacokinetics of parecoxib fits to a two-compartment model in Chinese patients.

About this research paper

What this paper is about

Objective To study the clinical pharmacokinetics of parecoxib in Chinese patients. Methods Twelve patients with ASA Ⅰ orⅡ undergoing elective surgery were injected parecoxib 40 mg.Blood samples were collected at 10 , 20 , 30 , 40 , 50and 60min , and 1.5 , 2 , 4 , 6 , 8 , 12 , 16 , 20 and 24hafter injection.The plasma concentration of parecoxib and its product valdecoxib were measured with high-performance liquid chromatography.The pharmacokinetic parameters were calculated with 3P97software package.Results The clinical pharmacokinetics of parecoxib is fitted to a two-compartment model.The main pharmacokinetic parameter including Cmax was ( 31.58±13.41 ) and ( 0.91±0.21 ) μ g / ml , Tmax was ( 10.00±0.00 ) min and ( 24.00±14.30 ) min , and t 1 / 2 β was ( 1.06±0.92 ) h and ( 10.65±3.20 ) h , respectively.Conclusion The clinical pharmacokinetics of parecoxib fits to a two-compartment model in Chinese patients.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the clinical pharmacokinetics of parecoxib in Chinese patients. Methods Twelve patients with ASA Ⅰ orⅡ undergoing elective surgery were injected parecoxib 40 mg.Blood samples were collected at 10 , 20 , 30 , 40 , 50and 60min , and 1.5 , 2 , 4 , 6 , 8 , 12 , 16 , 20 and 24hafter injection.The plasma concentration of parecoxib and its product valdecoxib were measured with high-performance liquid chromatography.The pharmacokinetic parameters were calculated with 3P97software package.Results The clinical pharmacokinetics of parecoxib is fitted to a two-compartment model.The main pharmacokinetic parameter including Cmax was ( 31.58±13.41 ) and ( 0.91±0.21 ) μ g / ml , Tmax was ( 10.00±0.00 ) min and ( 24.00±14.30 ) min , and t 1 / 2 β was ( 1.06±0.92 ) h and ( 10.65±3.20 ) h , respectively.Conclusion The clinical pharmacokinetics of parecoxib fits to a two-compartment model in Chinese patients.

Key concepts: Parecoxib, Valdecoxib, Pharmacokinetics, Medicine, Cmax, Plasma concentration, Anesthesia, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The clinical pharmacokinetics of parecoxib in Chinese patients — Research Paper | ScholarLens