Clinical study on concurrent chemoradiotherapy for locally advanced cervical cancer

Objective To investigate the effectiveness and side effects of concurrent chemoradiotherapy for locally advanced cervical cancer.Methods 78 pathologically verified cases of Ⅱb-Ⅳa cervical cancer were randomly divided into a treatment group(group A,n=42) and a radiotherapy control group(group B,n=42).Both groups underwent radiotherapy,using 6 MV-X ray for external radiation with a total dose of 45-50 Gy and 192Ir afterloading unit for brachytherapy at the dose of 7 Gy per week at point A with a total dose of 35-42 Gy.The group A patients were synchronously given cisplatin(DDP) 20 mg,5-FU 500 mg and calcium folinate(CF) 100 mg,qd from d1 to d5 in the 1st,4th and 7th weeks.The short-term effect,5-year survival rate and complications were noted.Results The effective rate 3 months after radiotherapy was 95.0% in group A and 72.2% in group B,showing a significant difference(P0.05).The 5-year survival rate was higher in group A(61.9%) than in group B(36.1%)(P0.05).The complications,though higher in group A than in group B,were tolerable and not aggravated later.Conclusion Concurrent chemoradiotherapy can remarkably increase the survival rate in patients with locally advanced cervical cancer.