Application of acellular dermis matrix in dermal wound

Objective To discuss the effect of cover allogeneic skin on severe damaged wound, accelerate wound bed preparation and wound’s healing. Methods Eighty-four emergency patients were selected who had severe damaged wound in skin and soft tissues during June 2005 to June 2011. According to the different treatments, the patients were divided into two groups. The former had 41 cases using allogeneic skin cover as treatment group and the latter had 43 cases using first stage skin grafting as control group. The success rate and healing rate of this two treatments were observed. Results After two regular debridement, group A were covered with acellular dermis matrix (ADM), group B were covered with the Saline gauze and the Vaseline oil sands. Every 4 cm × 4 cm size of the wound of each patient was selected as a viewing area. The growth of granulation tissue and clinical treatment time of two groups were compared after treated 1 d, 3 d, 7 d, 12 d. Results After treatment of 7 d, granulation wounds of group A (24.87±0.24) were significantly different compared with group B (18.66±0.45). The time of wound healing in group A was (16.17 ± 1.87) d, which was significantly shorter than group B (32.71±3.95) d, and the difference was highly statistically significant (P 0.01). Conclusion As a wound cover allogeneic skin, it can effectively protect the wound and promote wound vascularization and shorten the clinical treatment cycle.