Research Progress of S100B Protein in the Early Diagnosis of Brain Damage after Birth Asphyxia

Birth asphyxia accounts for a significant percentage of neonatal morbidity and mortality. A key factor in the management of this complication is the early and accurate detection of brain damage after asphyxia. Latest studies illustrate that serum and urine S100B is promising to become an early marker for diagnosis of brain damage. Under physiological conditions,S100B protein has neurotrophic role,but excessive secretion will cause neurotoxicity. It's known that serum S100B protein level increase is positively correlated with brain damage degree,which can be used for the early diagnosis and prognosis assessment of brain damage after birth asphyxia. This review summarizes the value of S100B in the early diagnosis of brain damage after birth asphyxia.