Potentially Useful Serological Methods for Screening Precancerous Changes and Gastric Cancer

Objective:To explore the relationship between the serum pepsinogen leveland gastrin with atrophic gastritis and gastric cancer.Methods:PepsinogenⅠandⅡ(PGI and PGⅡ)and serum gastrin were detected in 154 patients who have been un- dergone upper gastrointestinal endoscopy and biopsy,including 59 non-atrophic gastritis,52 atrophic gastritis and 43 gastric cancer.Results:The PGⅠlevel and the PGⅠ/PGⅡratio and serum gastrin in gastric cancer and atrophic gastritis patients were significantly different(P＜0.01)from the ones in the non-atrophic gastritis.The serum PGⅠlevel and the PGⅠ/PGⅡratio in a- trophic corpus-antral gastritis patients were significantly different from the ones in the atrophic corpus gastritis or atrophic an- tral gastritis(P＜0.05).No significant difference in serum pepsinogenⅠlevel and the PGⅠ/PGⅡratio were detected in atrophic gastritis and gastric cancer patients(P＞0.05).The serum gastrin level in atrophic corpus-antral gastritis and atrophic ant ral gastritis patients were significantly different from the ones in the atrophic corpus gastritis(P＜0.05).No significant difference in serum gastrin level were detected in atrophic corpus-antral gastritis and atrophic antral gastritis patients(P=0.680).Con- clusion:The plasma levels of the serum levels of PGⅠand the PGⅠ/Ⅱratio as well as serum gastrin could be potentially useful non-invasive marker for screening precancerous changes.