The Efficacy Analysis of Intensity-modulated radiotherapy Combined with Chemotherapy Maintenance Treatment for Advanced Esophageal Cancer

Objective To explore the efficacy of intensity-modulated radiotherapy combined with chemotherapy maintenance treatment for advanced esophageal cancer. Methods 86 stage Ⅲ / Ⅳ advanced esophageal cancer patients were collected and randomly divided into the experimental group( intensity-modulated radiotherapy combined with chemotherapy and capecitabine maintenance treatment) and the control group( intensity-modulated radiotherapy combined with chemotherapy),each group had 43 cases. The patients of the 2 groups were given the same radiotherapy and chemotherapy. On the 1st day of radiotherapy,the patients were given intravenous infusion of Docetaxelv 75 mg / m2on day 1;and intravenous infusion of Cisplatin 25 mg / m2on day 1-3,3 weeks was a cycle. After radiotherapy,the experimental group received capecitabine maintenance treatment. Short-term efficacy and survival of the 2 groups were compared. Results Effective rates of the 2 groups were 90. 70% and 88. 37%,the difference was not statistically significant( P 0. 05). The 1-,2-,3-year survival rates of the experimental group were 83. 72% 、 46. 51% and 23. 26%,The 1-,2-,3-year survival rates of the control group were 60. 47% 、27. 91% and 11. 63%,there had statistical difference( χ2= 5. 14,P = 0. 015). Conclusion Intensity-modulated radiotherapy combined with chemotherapy maintenance treatment for advanced esophageal cancer has better efficacy and survival.