Preparation of Low Molecular Weight Heparin-Chitosan-Sodium Carboxymethyl Cellulose Microcapsules and Its Drug-Release Performances

Low molecular weight heparin-chitosan-sodium carboxymethyl cellulose microcapsules were prepared bymeans of emulsion-dispersion cross-linking method. The influence factors of the different preparations on the drug-releaseperformances of the microcapsules were investigated. The results showed that the microcapsules prepared by optimizedconditions were smooth spherical with 2～7μm diameter. Encapsulation efficiency and drug loading were 92.3% and 6.47%,respectively. The release rate of the microcapsules was dependent on pH value of the media. The result tested in rabbitsindicated that the microcapsules had a significant sustained release effect compared with the injection.