2000•PubMedRequires access

[Expression of p53 protein during 4NQO-induced lingual carcinogenesis in two strains of rats].

Tao Li

Abstract

OBJECTIVE: To investigate p53 protein expression during lingual carcinogenesis in two strains of rats. METHODS: Dark-Agouti (DA) and Wistar/Furth (WF) rats were administrated with 4-nitroquinoline 1-oxide (4NQO) in drinking water and expression of p53 was studied using experimental materials obtained at 2, 4, 8, 12, 16, and 26 weeks of 4NQO treatment. RESULTS: Epithelial clusters of p53 positive cells appeared earlier and more in numbers in DA rats than in WF. A marked increase of p53+ clusters in DA rats was noted at later stages of the experiment, whereas those in WF rats appeared to be unchanged. CONCLUSIONS: These results suggest that there may be genetically determined variations in the p53 response to 4NQO between DA and WF rats, and these differences may contribute to their contrasting susceptibility during lingual carcinogenesis.

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Key concepts: 4-Nitroquinoline 1-oxide, Carcinogenesis, P53 protein, Biology, Protein expression, Internal medicine, Endocrinology, Gene