Expression and significance of P_(53)、P_(21)and CD_(44V6) protein in gastric cardiac carcinoma

Objective To study the correlation of the expression of P 53 ?P 21 and CD 44V6 protein with biological behaviors in gastric cardiac carcinoma.Methods The expressions of P 53 ?P 21 and CD 44V6 protein were determined by immunohistochemical method in 41 cases of gastric cardiac carcinoma.Results The positive rates of P 53 ?P 21 and CD 44V6 protein were 75.6%.53.6% and 41.4% respectively.There were no significant correlation between the expression of P 53 ?P 21 and CD 44V6 protein and sex.age,clinical stages and histopathological types of patients.The expression of CD 44V6 protein showed significant correlation with the depth of tumor invation ( P 0 05).The expression of P 53 was positively correlated with that of P 21 ( P 0 05).The prognosis with positive expression of P 53 ?P 21 and CD 44V6 protein was bad than that negative expression.Conclusion The expression of P 53 ?P 21 and CD 44V6 protein might be useful for evaluating the prognosis of gastric cardiac carcinoma.