Fasudil: a novel drug for cardio-cerebral vascular system

Fasudil, the only Rho-kinase inhibitor available in clinical and a novel intracellular calcium antagonist, can increase regional blood flow and protect brain tissue, is mainly used to prevent cerebral vasospasm, cerabral ischemia, etc. after the surgery for subarachnoid hemorrhage. The system of Rho/Rho kinases is important in life activities. With the progress of the research, the molecular mechanism for the regulation of Rho-kinase by fasudil becomes clear. Fasudil is in terminal clinical trials for more applications and is prospect in the treatment of cardio-cerebral vascular diseases.