Influences of Ropivacaine in Epidural Anesthesia on Effects of Propofol Target-controlled Infusion during Induction of General Anesthesia in Elderly Patients

Objective:To observe influences of ropivacaine in epidural anesthesia on effects of propofol target-controlled infusion during induction of general anesthesia in elderly patients,and to discuss the probably mechanism.Methods:Forty elderly patients were randomly divided into two groups: ropivacaine group(GR,n=20)and physiological saline control group(GS,n=20).Patients in the two groups were given 0.5%ropivacaine(GR)and physiological saline(GS)for epidural anesthesia respectively,observing the efficacy of sensory and motor block.Target controlled infusion of propofol during induction of general anesthesia,time of consciousness disappear,propofol diprivan concentration and the doses of propofol were recorded.Results: Time of consciousness disappear in ropivacaine group was 20% less than physiological saline group(P0.05).Propofol diprivan concentration and dose in ropivacaine group were lower than control group(P0.05).There was no significant difference between the two groups in the basal BIS value,BIS value 15 minutes after epidural injection,during consciousness disappear,the BIS value during and after tracheal intubations(P0.05).There were significant discrepancy in basal BIS value and the BIS value during consciousness disappear in two groups(P0.05).The MAP value 15 minutes after epidural injection,during consciousness disappear and 1 min after tracheal intubations in ropivacaine group were lower,compared with control group(P0.05).Conclusion: Propofol target-controlled infusion epidural anesthesia during induction of general anesthesia combined epidural anesthesia in elderly patients can be significantly decrease the dose of propofol and time of consciousness disappear,suppress the response to tracheal intubation and debase the possible side-effect of general anesthesia drugs.