EXPRESSION OF CD117、C-ERB-2 AND KI-67 IN HEPATOCELLULAR CARCINOMA AND THEIR SIGNIFICANCE

Objective To explore the expression of CD117、C-erbB-2 and Ki-67 in hepatocellular carcinoma(HCC) and its clinical significance.Methods The expression of CD117、C-erbB-2 and Ki-67 were evaluated by Envion immunohistochemical staining in 56 cases of HCC and 30 cases of liver cirrhotic specimens,as well as 10 cases of normal liver specimens.Results The positive expression of CD117 was found in 32.1% of HCC,33.3% of cirrhostic liver specimens,and 20% of normal liver specimens,respectively.There was no significant difference among the three groups,but the CD117 expression was significant associated with the histological grades and clinical stages.The positive expression of C-erbB-2 was 51.8%,63.3% and 30% in HCC,cirrhotic liver specimens and normal liver tissues,respectively.Moreover,statistical difference was found in the expression of C-erbB-2 among three groups.The C-erbB-2 expression was not related to histological grades,but dramatically related to the clinical stages.The positive expression of Ki-67 was 65.8%,28.5% and 19.3% in HCC,cirrhotic liver specimens and normal liver tissues,respectively.statistical difference was found in the expression of Ki-67 among three groups.Conclusion CD117 and C-erbB-2 may play important role in liver carcinogenesis and the progression of HCC,and Ki-67 may be used as a prognostic index.