Functions of Propofol on the Lung Injury Induced by Intestinal Ischemia/Reperfusion in Rats

Objective To research the functions of different clinical doses of propofol on the lung injury induced by intestinal ischemia-reperfusion(I-R) in rats.Methods Forty male SD rats weighing 160～200g were used.The animals were randomly divided into 5 groups with 10 animals in each group: ①control group was sham-operated;②I-R group and ③～⑤ I-R+propofol group in which propofol was infused at 2,6 or 8mg·kg~(-1)·h~(-1),starting from 10 min before intestinal ischemia until the end of experiment.The animals were killed at the end of 120 min reperfusion.The lungs were immediately removed for determination of lung W/D weight ratio and myeloperoxidase(MPO) activity in the lung tissue.Results Propofol infusion significantly inhibited the increased MPO activity and the increased lung W/D ratio induced by intestinal I-R and ameliorated the morphological changes of the lungs.Lung W/D ratio was positively correlated with MPO activity.Conclusion After the intestinal I-R,the different clinical doses of propofol have protective effects on the lungs against intestinal I-R-induced injury.