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Effects of PTS on Expression of Nestin following Focal Ischemia-Reperfusion in Rats

Zhou Dong

Abstract

Objective:To study the expression of Nestin and the effect of PTS on it following focal ischemia-reperfusion in the adult rat brain.Metheods:The model of acute reperfusion injury after cerebral ischemia in rats was made by middle cerebral artery occlusion.All animals were allowed 2h ischemia and sacrificed after different durations of reperfusion (3h,6h,24h,48h,72h,7d,14d).The expression of Nestin was detected with an immunohistochemical approach.Results:The number of Nestin-immunoreactive cells at 24h after reperfusion in ischemic side in PTS group started to increase markedly and represent significant difference compared with the N.S group,peaked on 7d and then decreased observably on 14 d after reperfusion.Conclusion:The study implies PTS could up-regulate the expression of Nestin,and it might be the one of protective mechanisms of PTS against ischemia-reperfusion injury.

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Key concepts: Nestin, Medicine, Ischemia, Immunohistochemistry, Reperfusion injury, Middle cerebral artery, Occlusion, Internal medicine