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2014•Shiyong yaowu yu linchuangRequires access

Effect and safety of prednisone combined with leflunomide treatment for elderly patients with rheumatoid arthritis

Yin Sun

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Abstract

Objective To evaluate the efficacy and safety of prednisone combined with leflunomide( LEF) on elderly patients with rheumatoid arthritis. Methods The records of 50 cases of elder patients with rheumatoid arthritis treated with prednisone and LEF were retrospectively reviewed. Results Out of 50 cases,33 cases were remarkable effective,13 cases were effective,the total effective rate was 92. 0%. The adverse reactions included gastrointestinal reactions,oral ulcers,leucopenia,liver damage and blood sugar increasing. Conclusion Prednisone combined with LEF plus appropriate management is effective and safe for the elderly patients with rheumatoid arthritis with less adverse reactions.

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What this paper is about

Objective To evaluate the efficacy and safety of prednisone combined with leflunomide( LEF) on elderly patients with rheumatoid arthritis. Methods The records of 50 cases of elder patients with rheumatoid arthritis treated with prednisone and LEF were retrospectively reviewed. Results Out of 50 cases,33 cases were remarkable effective,13 cases were effective,the total effective rate was 92. 0%. The adverse reactions included gastrointestinal reactions,oral ulcers,leucopenia,liver damage and blood sugar increasing. Conclusion Prednisone combined with LEF plus appropriate management is effective and safe for the elderly patients with rheumatoid arthritis with less adverse reactions.

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Available abstract

Objective To evaluate the efficacy and safety of prednisone combined with leflunomide( LEF) on elderly patients with rheumatoid arthritis. Methods The records of 50 cases of elder patients with rheumatoid arthritis treated with prednisone and LEF were retrospectively reviewed. Results Out of 50 cases,33 cases were remarkable effective,13 cases were effective,the total effective rate was 92. 0%. The adverse reactions included gastrointestinal reactions,oral ulcers,leucopenia,liver damage and blood sugar increasing. Conclusion Prednisone combined with LEF plus appropriate management is effective and safe for the elderly patients with rheumatoid arthritis with less adverse reactions.

Key concepts: Leflunomide, Rheumatoid arthritis, Medicine, Prednisone, Adverse effect, Internal medicine, Gastroenterology, Arthritis

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