[Genetic characteristics of six Chinese Han keloid pedigrees].

OBJECTIVE: To study the genetic characteristics of keloid in 6 Chinese Han pedigrees. METHODS: The clinical data of 6 unrelated Chinese Han keloid pedigrees were collected, and their pedigree charts were constructed and the inheritance patterns analyzed. RESULTS: Keloid onset in the patients of these pedigrees mainly occurred during adolescence, with equal chance for involvement in male and female subjects. The affected individual could be heterozygous, and a child with one affected parent had a 50% chance of being affected. The trait of keloid was transmitted consecutively in 3 pedigrees, showing complete penetrance, but in the other 3 pedigrees, it was transmitted intermittently, suggesting incomplete penetrance. The clinical phenotype of keloid presented a variable expression among the affected individuals in these pedigrees. CONCLUSION: The inheritance pattern observed in these Chinese Han keloid pedigrees is consistent with an autosomal dominant inheritance with incomplete penetrance, variable expressivity and delayed dominance.