Outcomes of Noninvasive Positive Pressure Ventilation for Treatment of Chronic Obstructive Pulmonary Disease

Objective:To evaluate the efficacy of noninvasive bi-level positive pressure ventilation (Bi-PAP) for treatment of chronic obstructive pulmonary disease(COPD) complicated with type-Ⅱ respiratory failure.Methods: Fifty-four COPD patients complicated with type-Ⅱ respiratory failure were treated on Bi-PAP ventilator in a noninvasive positive pressure ventilation(NPPV)approach.Bloodgas analysis was performed at 1 h,2 h and at the end of NPPV.Changes in arterial pH,PaO2 and PaCO2 were also compared among the patients.Results: The value of arterial pH significantly increased at 1h of NPPV 1 h(P0.05) and became even higher at 2 h and at the end of NPPV(both P0.01);the value of PaO2 significantly increased at 1 h and 2 h of NPPV(both P0.05) and became even higher at the end of NPPV(P0.01);the value of PCO2 significantly declined at 1 h of NPPV(P0.05) and became further decreased at 2 h and at the end of NPPV(both P0.01).Of these 54 patients,42 showed improved clinical signs and were discharged later,4 could not tolerate the treatment and were discontinued from NPPV,while 8 did not showed any improvement.Conclusion: The efficacy of NPPV treatment for COPD patients with type-Ⅱ respiratory failure appeared remarkable.