Relationship between Plasma Level of B-type Natriuretic Peptide and the Prognosis of Patients with Myocardial Infarction

Objective To explore the value of B-type natriuretic peptide(BNP) in estimating the risk in patients with acute myocardial infarction(AMI) and determining the relationship between BNP and adverse cardiac events after AMI.Methods The study included 80 AMI patients and 49 healthy subjects(with normal heart function).Plasma BNP level was measured by ELISA.Patients were followed to survey the prognosis(have cardiac events or not) next 16 months.Results Plasma BNP concentration in AMI patients was much higher than healthy subjects(1784.40±1593.40 ng/L versus 72.93±32.32ng/L,P0.05).Patients had cardiac events after AMI,the BNP concentration was higher than those no cardiac events patients(2230.81 ± 1870.28ng/L versus 1374.50 ± 1011.42ng/L,P0.05).With the concentration of BNP increasing,the probability of cardiac events oc-curring is rising.When the BNP concentration1 500ng/L,the probability is 30%,when its 1 500~3 000ng/L,the probability is 42.86%,and the concentration3 000ng/L,the probability rises to 62.5%,the positive rate of these three group have difference(P0.05).The data of logistic analysis show that BNP is a risk factor of poor outcomes in AMI patients.Conclusion The results of the present study confirm that the elevated BNP concentration related to the bad prognosis in patients with AMI and a higher incidence of new cardiac events after AMI.With the concentra-tion of BNP rising,the probability of cardiac events occurring was higher.It can be used as an independent predictor of poor outcomes in AMI patients.