Pregnancy-associated plasma protein-A polymorphism and the risk of pre-eclampsia

Objective:To estimate whether PAPP-A(Pregnancy-associated plasma protein-A) polymorphism is associated with pre-eclampsia.Methods:By means of polymerase Chain Reaction and Single-Strand Conformation Polymorphism,S1224Y(A /C)(dbSNP:rs7020782) polymorphism in the PAPP-A gene was detected in 129 women with pre-eclampsia(64 with mild pre-eclampsia and 65 with severe preeclampsia) and 137 normal control women with uncomplicated pregnancy.Investigators were blinded to clinical outcomes.Results:AC genotype frequency in pre-eclampsia group were higher than those in control group(44.2% VS 31.4%)(P﹤ 0.05);AC genotype frequency in severe pre-eclampsia group were significantly higher than those in mild pre-eclampsia group(75.4% VS 12.5%)(P﹤0.001).C allele frequency in severe pre-eclampsia group were significantly higher than those in mild pre-eclampsia group(40.8% VS 18.7%)(P﹤0.001).Conclusion:The AC genotype and C allele of S1224Y(A /C) polymorphism in the PAPP-A gene might be a risk genetic marker of pre-eclampsia.In patients with pre-eclampsia,there is the association between AC genotype and C allele of PAPP-A gene and severity of pre-eclampsia.