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2005•Journal of Qilu OncologyRequires access

Expression of LKB1 protein and its clinical significance in lung adenocarcinomas

Ding Xin-min

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Abstract

OBJECTIVE:To study the expression of LKB1 protein and its clinical significance in lung adenocarcinomas. METHODS: Immunohistochemical staining was performed with LKB1 antibody to the surgically resected tissue samples from 62 patients with lung adenocarcinoma.RESULTS: The negative rate of the expression LKB1 protein in lung adenocinoma was 38.7%(24/62). The expression LKB1 protein was associated with the extent of lymph node metastasis (χ2=10.620,P=0.014)and clinical stages,χ2=18.635,P=0.000. The median survival time was 15 months in the LKB1 protein negative expression group, however, 29 months in the LKB1 protein positive expression group,χ2=15.350,P=0.000. CONCLUSION: Loss LKB1 expression in lung adenocarcinoma may contribute to the lymph node metastasis, and this may be a risky factor for the prognosis of patients with lung adenocarcinoma.

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OBJECTIVE:To study the expression of LKB1 protein and its clinical significance in lung adenocarcinomas. METHODS: Immunohistochemical staining was performed with LKB1 antibody to the surgically resected tissue samples from 62 patients with lung adenocarcinoma.RESULTS: The negative rate of the expression LKB1 protein in lung adenocinoma was 38.7%(24/62). The expression LKB1 protein was associated with the extent of lymph node metastasis (χ2=10.620,P=0.014)and clinical stages,χ2=18.635,P=0.000. The median survival time was 15 months in the LKB1 protein negative expression group, however, 29 months in the LKB1 protein positive expression group,χ2=15.350,P=0.000. CONCLUSION: Loss LKB1 expression in lung adenocarcinoma may contribute to the lymph node metastasis, and this may be a risky factor for the prognosis of patients with lung adenocarcinoma.

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Available abstract

OBJECTIVE:To study the expression of LKB1 protein and its clinical significance in lung adenocarcinomas. METHODS: Immunohistochemical staining was performed with LKB1 antibody to the surgically resected tissue samples from 62 patients with lung adenocarcinoma.RESULTS: The negative rate of the expression LKB1 protein in lung adenocinoma was 38.7%(24/62). The expression LKB1 protein was associated with the extent of lymph node metastasis (χ2=10.620,P=0.014)and clinical stages,χ2=18.635,P=0.000. The median survival time was 15 months in the LKB1 protein negative expression group, however, 29 months in the LKB1 protein positive expression group,χ2=15.350,P=0.000. CONCLUSION: Loss LKB1 expression in lung adenocarcinoma may contribute to the lymph node metastasis, and this may be a risky factor for the prognosis of patients with lung adenocarcinoma.

Key concepts: Immunohistochemistry, Adenocarcinoma, Lung, Clinical significance, Medicine, Pathology, Lymph node, Protein expression

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