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Protective effects of sodium fulvit on hepatic ischemia/reperfusion injury after liver cirrhosis in rats

Ying Qing Mao

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Abstract

Objective To investigate the protective effects of sodium fulvit on hepatic ischemia/reperfusion (I/R) injury in rats with liver cirrhosis. Methods After the model of liver cirrhosis was successfully in rats using CCl 4, 2% sodium fulvit was given by gaugue at the dose of 100 μg/kg/d twice a day for 3 days. Then the hepatic portal vein was clamped twice and sample samples were collected from the inferior hepatic vain to determine values of ET-1, TNF-α and IL-6. Liver tissue samples from the left lobe were stained with HE and observed under light microscope. Results The values of ET-1, TNF-α and IL-6 were significantly lower in sodium fulvit-administered rats than in the controls (P0.05). Microscopic examination showed that the hepatic injury was milder in the sodium fulvit-administered rats than in the controls. Conclusions Sodium fulvit administered by gaugue before operation can protect the liver from I/R injury in rats with liver cirrhosis.

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What this paper is about

Objective To investigate the protective effects of sodium fulvit on hepatic ischemia/reperfusion (I/R) injury in rats with liver cirrhosis. Methods After the model of liver cirrhosis was successfully in rats using CCl 4, 2% sodium fulvit was given by gaugue at the dose of 100 μg/kg/d twice a day for 3 days. Then the hepatic portal vein was clamped twice and sample samples were collected from the inferior hepatic vain to determine values of ET-1, TNF-α and IL-6. Liver tissue samples from the left lobe were stained with HE and observed under light microscope. Results The values of ET-1, TNF-α and IL-6 were significantly lower in sodium fulvit-administered rats than in the controls (P0.05). Microscopic examination showed that the hepatic injury was milder in the sodium fulvit-administered rats than in the controls. Conclusions Sodium fulvit administered by gaugue before operation can protect the liver from I/R injury in rats with liver cirrhosis.

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Available abstract

Objective To investigate the protective effects of sodium fulvit on hepatic ischemia/reperfusion (I/R) injury in rats with liver cirrhosis. Methods After the model of liver cirrhosis was successfully in rats using CCl 4, 2% sodium fulvit was given by gaugue at the dose of 100 μg/kg/d twice a day for 3 days. Then the hepatic portal vein was clamped twice and sample samples were collected from the inferior hepatic vain to determine values of ET-1, TNF-α and IL-6. Liver tissue samples from the left lobe were stained with HE and observed under light microscope. Results The values of ET-1, TNF-α and IL-6 were significantly lower in sodium fulvit-administered rats than in the controls (P0.05). Microscopic examination showed that the hepatic injury was milder in the sodium fulvit-administered rats than in the controls. Conclusions Sodium fulvit administered by gaugue before operation can protect the liver from I/R injury in rats with liver cirrhosis.

Key concepts: Cirrhosis, Sodium, Ischemia, Medicine, Internal medicine, Gastroenterology, Reperfusion injury, Vein

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Protective effects of sodium fulvit on hepatic ischemia/reperfusion injury after liver cirrhosis in rats — Research Paper | ScholarLens