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Optimized Formulation of Weikangshu Tablets by Central Composite Design /Response Surface Methodology

Jingsheng Du

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Abstract

Objective:To optimize the formulation of Weikangshu tablets by central composite design/response surface methodology.Methods:Independent variables were L-HPC content and CMC-Na content,disintegrating time and breakage were dependent variable.Linear or nonlinear mathematic models were used to estimate the relationship between independent and dependent variables.Response surfaces were delineated according to best-fit mathematic models,and optimum formulations were selected.Prediction was carried out through comparing the observed and predicted values.Results:Optimized formulation of Weikangshu tablets was proposed to consist of 8.16%～9.27% L-HPC and 1.9%～2.71% CMC-Na.Bias between the observed and predicted values was within 6%.Conclusion:It shows that the optimum mathematic model is highly predictive.

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What this paper is about

Objective:To optimize the formulation of Weikangshu tablets by central composite design/response surface methodology.Methods:Independent variables were L-HPC content and CMC-Na content,disintegrating time and breakage were dependent variable.Linear or nonlinear mathematic models were used to estimate the relationship between independent and dependent variables.Response surfaces were delineated according to best-fit mathematic models,and optimum formulations were selected.Prediction was carried out through comparing the observed and predicted values.Results:Optimized formulation of Weikangshu tablets was proposed to consist of 8.16%～9.27% L-HPC and 1.9%～2.71% CMC-Na.Bias between the observed and predicted values was within 6%.Conclusion:It shows that the optimum mathematic model is highly predictive.

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Available abstract

Objective:To optimize the formulation of Weikangshu tablets by central composite design/response surface methodology.Methods:Independent variables were L-HPC content and CMC-Na content,disintegrating time and breakage were dependent variable.Linear or nonlinear mathematic models were used to estimate the relationship between independent and dependent variables.Response surfaces were delineated according to best-fit mathematic models,and optimum formulations were selected.Prediction was carried out through comparing the observed and predicted values.Results:Optimized formulation of Weikangshu tablets was proposed to consist of 8.16%～9.27% L-HPC and 1.9%～2.71% CMC-Na.Bias between the observed and predicted values was within 6%.Conclusion:It shows that the optimum mathematic model is highly predictive.

Key concepts: Central composite design, Response surface methodology, Composite number, Breakage, Mathematics, Variable (mathematics), Variables, Materials science

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