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The mechanism of acute lung injury during severe acute pancreatitis in rats

Qing-Ping Wen

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Abstract

Objective To study the role of endotoxin(ET),tumor necrosis factor(TNF),interleukin-6(IL-6),and oxygen free radicals(OFR)in rats with acute lung injury(ALI)induced by severe acute pancreatits(SAP).Methods 1.5% sodium deoxycholate was injected retrogradely into the common biliopancreatic duct in rats to produce the model of ALI during SAP.The rats were devided randomly into 2 groups:sham operation control group(n=10)and SAP model group(n=30).All rats were killed at 24 hours after operation and treatment.The level of ET,TNF,IL-6,MDA,SOD in serum and pulmonary homogenate were measured.Results The level of ET,TNF,IL-6,SOD,MDA in serum and pulmonary homogenate in SAP group were significantly higher than those in sham operation control group(P0.01).The indexes of blood gas analysis and the lung tissue showed obvious pathologic changes in SAP group.Conclusion ET,TNF,IL-6,and OFR play an important role in ALI caused by SAP.

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What this paper is about

Objective To study the role of endotoxin(ET),tumor necrosis factor(TNF),interleukin-6(IL-6),and oxygen free radicals(OFR)in rats with acute lung injury(ALI)induced by severe acute pancreatits(SAP).Methods 1.5% sodium deoxycholate was injected retrogradely into the common biliopancreatic duct in rats to produce the model of ALI during SAP.The rats were devided randomly into 2 groups:sham operation control group(n=10)and SAP model group(n=30).All rats were killed at 24 hours after operation and treatment.The level of ET,TNF,IL-6,MDA,SOD in serum and pulmonary homogenate were measured.Results The level of ET,TNF,IL-6,SOD,MDA in serum and pulmonary homogenate in SAP group were significantly higher than those in sham operation control group(P0.01).The indexes of blood gas analysis and the lung tissue showed obvious pathologic changes in SAP group.Conclusion ET,TNF,IL-6,and OFR play an important role in ALI caused by SAP.

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Available abstract

Objective To study the role of endotoxin(ET),tumor necrosis factor(TNF),interleukin-6(IL-6),and oxygen free radicals(OFR)in rats with acute lung injury(ALI)induced by severe acute pancreatits(SAP).Methods 1.5% sodium deoxycholate was injected retrogradely into the common biliopancreatic duct in rats to produce the model of ALI during SAP.The rats were devided randomly into 2 groups:sham operation control group(n=10)and SAP model group(n=30).All rats were killed at 24 hours after operation and treatment.The level of ET,TNF,IL-6,MDA,SOD in serum and pulmonary homogenate were measured.Results The level of ET,TNF,IL-6,SOD,MDA in serum and pulmonary homogenate in SAP group were significantly higher than those in sham operation control group(P0.01).The indexes of blood gas analysis and the lung tissue showed obvious pathologic changes in SAP group.Conclusion ET,TNF,IL-6,and OFR play an important role in ALI caused by SAP.

Key concepts: Medicine, Acute pancreatitis, Lung, Tumor necrosis factor alpha, Internal medicine, Gastroenterology, Pancreatitis, Anesthesia

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