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2010•Chinese Journal of Birth Health & HeredityRequires access

HSP27:mechanisms of cellular protection against artery injury

Guanghui Yi

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Abstract

Heat shock protein 27 (HSP27) is an important member of small molecular weight heat shock protein family,upregulation when the body under stress,can protect cell function via the effect of molecular chaperone,regulating cell movement,anti apoptosis,anti-oxidative stress and anti-inflammatory.HSP27 is a recently reported potential biomarker of atherosclerosis.The serum HSP27 levels were inversely related to atherosclerotic burden.HSP27 may be a significant new therapeutic target in Atherosclerosis.

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What this paper is about

Heat shock protein 27 (HSP27) is an important member of small molecular weight heat shock protein family,upregulation when the body under stress,can protect cell function via the effect of molecular chaperone,regulating cell movement,anti apoptosis,anti-oxidative stress and anti-inflammatory.HSP27 is a recently reported potential biomarker of atherosclerosis.The serum HSP27 levels were inversely related to atherosclerotic burden.HSP27 may be a significant new therapeutic target in Atherosclerosis.

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Available abstract

Heat shock protein 27 (HSP27) is an important member of small molecular weight heat shock protein family,upregulation when the body under stress,can protect cell function via the effect of molecular chaperone,regulating cell movement,anti apoptosis,anti-oxidative stress and anti-inflammatory.HSP27 is a recently reported potential biomarker of atherosclerosis.The serum HSP27 levels were inversely related to atherosclerotic burden.HSP27 may be a significant new therapeutic target in Atherosclerosis.

Key concepts: Hsp27, Heat shock protein, Downregulation and upregulation, Oxidative stress, Hsp70, Apoptosis, Cell biology, Shock (circulatory)

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