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Synthesis and Antitumor Activity of Novel Castor Oil-based Quaternary Ammonium

Yang Xiao-hui

Abstract

Two kinds of novel castor oil-based quaternary ammonium were synthesized from the starting material of methyl ricinoleate by amidation reaction and quaternization reaction.Their structures were characterized by means of FTIR,1HNMR,13CNMR and ESI(MS).The bactericidal activity of the novel castor oil-based quaternary ammonium salts was evaluated by inhibitory zone diameters against E.coli and S.aureus.It is found that they have antibacterial activity.The antibacterial activity of N,N-dimethyl-N-ethyl-castor oil acid amide propyl bromide is stronger than that of N-benzyl-N,N-dimethyl-castor oil acid amide propyl bromide.

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Key concepts: Castor oil, Chemistry, Ammonium, Amide, Antibacterial activity, Ammonium bromide, Bromide, Organic chemistry