Cytogenetical analysis on 218 cases with chromosomal abnormality

Objective:To carry out cytogenetical analysis on 218 cases with chromosomal abnormality,understand the status of chromosomal abnormality in Guizhou,direct bearing and rearing better children and improve the quality of newborn babies.Methods:All the patients received history-taking and physical examination,then the cytogenetical analysis was carried out,the sequence was cultivation of lymphocytes from 1.5 milliliters venous blood,staining smear examination of metaphase chromosome,G binding and karyotype analysis.Results:Chromosomal abnormalities included: 150 cases of autosomal number and structural abnormality (68.8%),50 cases of heterosomal number and structural abnormality (22.94%),18 cases of chromosomal polymorphism (8.26%).Conclusion:Chromosomal abnormality is related to the history of adverse pregnancy,sterility and dysgenesis,feeblemindedness,abnormality of sexual development and primary amenorrhea.Genetic counseling of pregestational prepotency and understanding the status of chromosomal abnormality are important to clinical treatment and direct bearing and rearing better children.