The changes of platelet aggregation ratio in acute coronary syndrome patients with clopigogrel resistance following alternated by ticagrelor

Objective To observe the variance of the platelet aggregation ratio after using ticagrelor for instead of clopidogrel in acute coronary syndrome patients suffering from clopidogrel resistance,Methods Platelet aggregation ratio test induced by adenosine diphosphate(ADP) identified acute coronary syndrome patients with clopidogrel resistance underwent the PCI(percutaneous coronary intervention) from July 2013 to July 2014,The 57 patients with clopidogrel resistance were given 180 mg ticagrelor load followed by 90 mg twice daily maintenance therapy,for instead of clopidogrel 75 mg once daily for 1 month,and the platelet aggregation ratio were tested.Results Platelet aggregation rate had significant difference(P0.05) statistically after administration of ticagrelor compared with clopidogrel,Conclusion Compared with the regular-dose treatment of clopidogrel,ticagrel can effectively decrease the platelet aggregation ratio in acute coronary syndrome patients with clopidogrel resistance.