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The Application of Situ-isolated Lung Perfusion Rat Model in the Evaluation of Pulmonary Capillary Permeability

Qiang Dong

Abstract

Objective To evaluate pulmonary vascular permeability by using an improved situ-isolated lung perfusion rat model.Methods Based on traditional rat isolated lung perfusion methods,we established the improved situ-isolated lung perfusion rat model and Lipopolysaccharide(LPS)induced lung injury model.The content of Evans blue(EB)in lung was tested and the albumin permeability-surface area(PS)was caculated to quantitatively evaluate pulmonary vascular permeability.Results PS values of normal control and lung injury group were 5.37±0.94,25.00±8.8×10-2 cm3(/min.g),respectively.Conclusion The present evaluation method of pulmonary vascular permeability is simple,accurate positioning and reliable.

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Key concepts: Vascular permeability, Perfusion, Lung, Evans Blue, Permeability (electromagnetism), In situ, Lipopolysaccharide, Albumin