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2007•Journal of Beijing University of Chemical TechnologyRequires access

Synthesis of trimethylolheptane

Zhi Hong Xiao

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Abstract

Trimethylolheptane (TMH) was synthesized through consecutive aldol condensation and Cannizzaro reaction of octylaldehyde and formaldehyde, using sodium hydroxide as catalyst. The effects of varying the amount of catalyst, the ratio of reactants, temperature and time of the Cannizzaro reaction on the yield of TMH were investigated. A yield of 88% for TMH can be obtained by using the optimized synthetic conditions as follows: molar ratio of formaldehyde to octylaldehyde 4.5∶1.0, molar ratio of sodium hydroxide to octylaldehyde 1.4∶1.0, aldol condensation temperature 35 ℃ and time 240 min, Cannizzaro reaction temperature 55 ℃ and time 180 min. The purity of TMH was confirmed by 13C-Nuclear Magnetic Resonance (NMR) spectroscopy.

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What this paper is about

Trimethylolheptane (TMH) was synthesized through consecutive aldol condensation and Cannizzaro reaction of octylaldehyde and formaldehyde, using sodium hydroxide as catalyst. The effects of varying the amount of catalyst, the ratio of reactants, temperature and time of the Cannizzaro reaction on the yield of TMH were investigated. A yield of 88% for TMH can be obtained by using the optimized synthetic conditions as follows: molar ratio of formaldehyde to octylaldehyde 4.5∶1.0, molar ratio of sodium hydroxide to octylaldehyde 1.4∶1.0, aldol condensation temperature 35 ℃ and time 240 min, Cannizzaro reaction temperature 55 ℃ and time 180 min. The purity of TMH was confirmed by 13C-Nuclear Magnetic Resonance (NMR) spectroscopy.

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Available abstract

Trimethylolheptane (TMH) was synthesized through consecutive aldol condensation and Cannizzaro reaction of octylaldehyde and formaldehyde, using sodium hydroxide as catalyst. The effects of varying the amount of catalyst, the ratio of reactants, temperature and time of the Cannizzaro reaction on the yield of TMH were investigated. A yield of 88% for TMH can be obtained by using the optimized synthetic conditions as follows: molar ratio of formaldehyde to octylaldehyde 4.5∶1.0, molar ratio of sodium hydroxide to octylaldehyde 1.4∶1.0, aldol condensation temperature 35 ℃ and time 240 min, Cannizzaro reaction temperature 55 ℃ and time 180 min. The purity of TMH was confirmed by 13C-Nuclear Magnetic Resonance (NMR) spectroscopy.

Key concepts: Sodium hydroxide, Formaldehyde, Yield (engineering), Aldol condensation, Chemistry, Catalysis, Molar ratio, Aldol reaction

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