Inflammatory Factors and von Willebrand Factor in Hypertensive Patients Complicated with Metabolic Syndrome

Objective To test the hypothese that metabolic syndrome is closely associated with inflammation, we compare the difference of inflammatory factors and von Willebrand factor between essential hypertensives and hypertensive patients with metabolic syndrome. Methods According to the new definition of metabolic syndrome by IDF 2005, one hundred thirty eight consecutive hospitalized essential hypertensives were catelogorized into EH+MS group, n=99 and EH alone group, n=39. Biochemistry assay, white blood cell (WBC) counts, serum high sensitive C reactive protein (hsCRP) and plasma von Willebrand factor (vWF) were measured. The relationship between hsCRP, vWF and MS were analysed. Results Waist circumference, body mass index, triglyceride, low density lipoprotein cholesterol (LDL-C), WBC, serum hsCRP and plasma vWF were increased(P0.05 or P0.01, respectively), while high density lipoprotein cholesterol (HDL-C) was decreased (P0.01) in EH-MS group, compared with EH group. vWF was correlated significantly with hsCRP ( r=0.283, P0.01). Multiple regression analysis showed that vWF was correlated significantly with hsCRP, age, MS, DBP and smoke (P0.01, respectively). hsCRP also correlated with WBC (P0.01). Logistic regression showed HDL-C, TG, LDL-C and vWF were independent determinants for MS (P0.05 or P0.01, respectively). Conclusion Compared with essential hypertensives, the hypertensive patients with metabolic syndrome had more activated inflammation and more serious endothelial dysfunction. vWF was correlated significantly with hsCRP and independently related to MS in hypertensive patients.